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研究队伍

姓名：	秦波	性别：	男
学科类别：	化学生物学	职务：	课题组长
学历：	博士	职称：	研究员
电话：	0931-4968371	传真：	0086-931-8277088
电子邮件：	bqin@licp.cas.cn
通讯地址：	中国甘肃省兰州市天水中路18号vic115维多利亚

简　　历：

秦波，男，研究员（三级），硕士、博士生导师。vic115维多利亚“优秀人才计划”入选者、中国科学院“西部之光”联合学者、中国植物保护学会委员、中国植物保护学会植物化感作用专业委员会副主任委员。1999年毕业于vic115维多利亚，获理学博士学位。1999年至2006年先后在中国科学院上海药物研究所、英国John Innes Centre和美国Colorado State University从事天然产物化学及其生源代谢与植物化学生态学领域的博士后研究工作。2006-2008年在中药复方新药开发国家工程研究中心/北京中研同仁堂医药研发有限公司工作，任制剂研究室主任，2008年9月起在中国科学院西北特色植物资源化学重点实验室工作。
主要从事植物、微生物活性代谢物及植物化学生态学研究工作。

在Phytochemistry, Journal of Agricultural and Food Chemistry, Plant Physiology and Biochemistry, Systematic and Applied Microbiology, Industrial Crops and Products等学术刊物上，已发表学术论文100余篇，在化感物质植物毒活性研究方面发表的学术论文数量位于国际首位，在草地植物微生物研究方面发表的学术论文数量位于国际前列。获得科技成果1项，申报发明专利13件，授权7件，培养硕、博士研究生11余名，合作培养研究生7名。

近年来系统开展了植物化学生态学与微生态系统研究工作，采用土壤原位分析方法，明确了瑞香狼毒、珠芽蓼、喜马拉雅大戟等西部草地优势植物及黄芪、党参、当归、甘草、百合、半夏、木香等西北主要栽培中药材与马铃薯、烟草等其它经济作物化感物质的化学结构、构效关系、分泌途径及活性作用机理，揭示了草地毒性植物在局部草原地带大肆蔓延的分子机制；通过自毒化感物质研究，明晰了栽培作物连作障碍的化学成因；探究了化感物质介导的植物生态竞争与环境适应性次生代谢物及其分子调控机制。针对农业废弃物的资源化利用，开展了黄芪、烟草等栽培作物地上部位废弃植物资源化学成分研究，发现了新结构天然产物和新的活性化合物；设计合成了系列化感物质结构类似物，在明确活性物质及作用机理基础上，成功研制了新型环境友好型植物源杀线虫剂－卡诺杀线灵，并向企业完成了技术成果转让；突破了天然活性化合物化学合成与生物工程制备技术及再生植株培育技术体系，为植物源活性物质的可持续开发利用和脱毒种苗培育奠定了技术基础。在明晰植物根际及体内微生物群落结构的时空动态变化规律的基础上，构建了微生物的系统发育图谱，明确了微生物的生态功能，构建了库容量达3000种的植物基可培养微生物资源库；基于化感物质降解、植物营养元素有效利用及农业生态环境改良与农作物病虫害防治，研制出针对不同作物种类的专用复合微生物菌剂及其有机、无机制剂，完成了百吨级复合微生物菌剂的工业化生产，明确了复合微生物菌剂的生产工艺参数，制定了质量控制标准，开展了复合微生物菌剂的应用示范，并推广应用上万亩。

研究方向：

植物化感物质与天然源活性物质基础研究；

植物次生代谢与生态学作用机制研究；

植物化感作用与连作障碍形成机制研究；

生态功能分子及新型生物防控剂研究与应用。

获奖及荣誉：

承担科研项目：

中国科学院战略性先导科技专项（A类）专题1项；

国家重点研发计划子课题1项（2017YFD0200804-05）；

国家自然科学基金面上项目4项（31070386、31570354、21102154、22076195）；

中科院兰州化物所“优秀人才计划”项目；

中科院兰州化物所“一三五”规划重点培育项目；

甘肃省科技支撑计划—社会发展类项目（1011FKCA128）；

甘肃省农牧厅农业生物技术研究与应用开发项目（GNSW-2015-25）；

中科院“西部之光人才培养计划”联合学者项目及其它院地合作及横向项目的研究工作。

代表论著：

近五年发表的SCI论文：
1. Xiaoyan Yang, Hui Jin, Lihong Xu, Haiyan Cui, Aiyi Xin, Haoyue Liu, Bo Qin*. Diversity and Functions of Endophytic Fungi Associated with Roots and Leaves of Stipa purpurea in an Alpine Steppe at Qinghai-Tibet Plateau. Journal of Microbiology and Biotechnology, 2020, 30(7), 1027-1036.
2. Hui Jin, Hongru Guo, Xiaoyan Yang*, Aiyi Xin, Bo Qin*. Effect of allelochemicals, soil enzyme activity and environmental factors from Stellera chamaejasme L. on rhizosphere bacterial communities in the northern Tibetan plateau. Archives of Agronomy and Soil Science, 2020, doi: 10.1080/03650340.2020.1852549.
3. Heping Hui, Aiyi Xin, Haiyan Cui, Hui Jin, Xiaoyan Yang, Haoyue Liu, Bo Qin*. Anti-aging effects on Caenorhabditis elegans of a polysaccharide, O-acetyl glucomannan, from roots of Lilium davidii var. unicolor Cotton. International journal of biological macromolecules, 2020, 155, 846-852.
4. Aiyi Xin, Xiuzhuang Li, Xiaoyan Yang, Hui Jin, Ruiming Zhao, Jingkun Liu, Bo Qin*. The accumulation of reactive oxygen species in root tips casued by autotoxic allelochemicals - a significant factor for replant problem of Angelica sinensis (Oliv.) Diels. Industrial Crops and Products, 2019, 138, 111432.
5. Heping Hui, Hui Jin, Xiuzhuang Li*, Xiaoyan Yang, Haiyan Cui, Aiyi Xin, Ruiming Zhao, Bo Qin*. Purification, characterization and antioxidant activities of a polysaccharide from the roots of Lilium davidii var. unicolor Cotton. International Journal of Biological Macromolecules, 2019, 135, 1208–1216.
6. Heping Hui, Xiuzhuang Li, Hui Jin*, Xiaoyan Yang, Aiyi Xin, Ruiming Zhao, Bo Qin*. Structural characterization, antioxidant and antibacterial activities of two heteropolysaccharides purified from the bulbs of Lilium davidii var. unicolor Cotton. International Journal of Biological Macromolecules 2019, 133, 306–315.
7. Zhiqiang Yan, Xiaofeng He, Kai Guo, Xiuzhuang Li, Xiaoyan Yang, Hui Jin, Anxiang Su, Weili Zheng, Lihong Xu, Xiaoxia Song, Bo Qin*. Allelochemicals from the rhizosphere of Lanzhou lily: Discovery of the autotoxic compounds of a bulb crop. Scientia Horticulturae, 2019, 250, 121–126.
8. Jingkun Liu, Min Xie, Xiuzhuang Li*, Hui Jin, Xiaoyan Yang, Zhiqiang Yan, Anxiang Su, Bo Qin*. Main Allelochemicals from the Rhizosphere Soil of Saussurea lappa (Decne.) Sch. Bip. and Their Effects on Plants’ Antioxidase Systems. Molecules, 2018, 23(10), 2506.
9. Hui Jin, Haiyan Cui, Xiaoyan Yang, Lihong Xu, Xudong Li, Rentao Liu, Zhiqiang Yan, Xiuzhuang Li, Weili Zheng, Yuhui Zhao, Xiaoxia Song, Lihua Zhong, Anxiang Su, Bo Qin*. Nematicidal activity against Aphelenchoides besseyi and Ditylenchus destructor of three biflavonoids, isolated from roots of Stellera chamaejasme. Journal of Asia-Pacific Entomology, 2018, 21, 1473-1478.
10. Zhiqiang Yan, Dandan Wang, Haiyan Cui, Yuhe Sun, Xiaoyan Yang, Hui Jin, Yuhui Zhao, Xiuzhuang Li, Min Xie, Jingkun Liu, Bo Qin*. Effects of artemisinin on root gravitropic response and root system development in Arabidopsis thaliana. Plant Growth Regulation, 2018, 85, 211–220.
11. Hui Jin, Xiaoyan Yang, Rentao Liu, Zhiqiang Yan, Xudong Li, Xiuzhuang Li, Anxiang Su, Yuhui Zhao, Bo Qin*. Bacterial community structure associated with the rhizosphere soils and roots of Stellera chamaejasme L. along a Tibetan elevation gradient. Annals of Microbiology, 2018, 68, 273–286.
12. Jingkun Liu, Zhiqiang Yan, Xiuzhuang Li, Hui Jin, Xiaoyan Yang, Min Xie, Anxiang Su, Bo Qin*. Characterization of allelochemicals from the rhizosphere soil of Pinellia ternate (Thnub.) and their inhibition activity on protective enzymes. Applied Soil Ecology, 2018, 125, 301–306.
13. Min Xie, Jingkun Liu, Zhiqiang Yan, Xiuzhuang Li, Xiaoyan Yang, Hui Jin, Anxiang Su, and Bo Qin*. Bio-guided isolation of plant growth regulators from allelopathic plant-Codonopsis pilosula: phyto-selective activities and mechanisms. RSC Advances, 2018, 8, 13649–13655.
14. Xia Ren, Zhiqiang Yan, Xiaofeng He, Xiuzhuang Li, Bo Qin*. Allelopathic effect of β-cembrenediol and its mode of action: Induced oxidative stress in lettuce seedlings. Emirates Journal of Food and Agriculture, 2017, 29(6), 441–449.
15. Xia Ren, Zhiqiang Yan*, Xiaofeng He, Xiu-zhuang Li, Bo Qin*. Allelochemicals from Rhizosphere soils of Glycyrrhiza uralensis Fisch: discovery of the autotoxic compounds of a traditional herbal medicine. Industrial Crops and Products, 2017, 97, 302–307.
16. Kai Guo , Xiaofeng He , Dengxue Lu , Yanping Zhang , Xiuzhuang Li , Zhiqiang Yan, Bo Qin*. Cycloartane-type triterpenoids from Astragalus hoantchy Franch Natural Product Research, 2017, 31(3), 314–319.
17. Min Xie, Zhiqiang Yan*, Xia Ren, Xiuzhuang Li, and Bo Qin*. Codonopilate A, a Triterpenyl Ester as Main Autotoxin in Rhizosphere Soil of Codonopsis pilosula (Franch.) Nannf. Journal of Agricultural and Food Chemistry, 2017, 65, 2032–2038.
18. Le Pan, Xiuzhuang Li*, Hui Jin, Xiaoyan Yang, Bo Qin*. Antifungal activity of umbelliferone derivatives: Synthesis and structure-activity relationships. Microbial Pathogenesis, 2017, 104, 110–115.
19. Xiuzhuang Li, Zhiqiang Yan, Le Pan, Hui Jin, Xiaoyan Yang, Junde Liu, Xiaofeng He, Xia Ren, Min Xie, Kai Guo, Bo Qin*. Caffeic acid derivatives as growth inhibitors of Setaria viridis: Structureactivity relationships and mechanisms. Phytochemistry Letters, 2017, 20, 208–213.
20. Zhiqiang Yan, Dandan Wang, Haiyan Cui, Denghong Zhang, Yuhe Sun, Hui Jin, Xiuzhuang Li, Xiaoyan Yang, Hongru Guo, Xiaofeng He, Le Pan, Xia Ren, Kai Guo, Bo Qin*. Phytotoxicity mechanisms of two coumarin allelochemicals from Stellera chamaejasme in lettuce seedlings, Acta Physiologiae Plantarum, 2016, 38(10), 248.
21. Kai Guo, Xiaofeng He, Zhiqiang Yan, Xiuzhuang Li, Xia Ren, Le Pan and Bo Qin*. Allelochemicals from the Rhizosphere Soil of Cultivated Astragalus hoantchy. Journal of Agricultural and Food Chemistry, 2016, 64, 3345？3352.
22. Kai Guo, Xiaofeng He, Yanping Zhang, Xiuzhuang Li, Zhiqiang Yan, Le Pan, Bo Qin*. Flavoniods from aerial parts of Astragalus hoantchy. Fitoterapia, 2016, 114, 34–39.
23. Hongru Guo, Liming Zeng, Zhiqiang Yan, Hui Jin, Xiuzhuang Li, Jinfeng Guan and Bo Qin*. Allelochemical from the root exudates of Stellera chamaejasme L. and its degradation. Allelopathy Journal, 2016, 38(1), 103–112.
24. Le Pan, Xiuzhuang Li, Di-an Sun, Hui Jin, Hongru Guo, Bo Qin*. Design and synthesis of novel coumarin analogs and their nematicidal activity against five phytonematodes. Chinese Chemical Letters, 2016, 27, 375–379.
25. Le Pan, Xiuzhuang Li, Chengwen Gong, Hui Jin, Bo Qin*. Synthesis of N-substituted phthalimides and their antifungal activity against Alternaria solani and Botrytis cinerea. Microbial Pathogenesis, 2016, 95, 186–192.
26. Xiaofeng He, Xiaodong Hou, Xia Ren, Kai Guo, Xiuzhuang Li, Zhiqiang Yan, Yongmei Du, Zhongfeng Zhang, Bo Qin*. Two new cembranic diterpenoids from the flowers of Nicotiana tabacum L. Phytochemistry Letters, 2016, 15, 238–244.
27. Dengxue Lu, Hui Jin, Xiaoyan Yang, Denghong Zhang, Zhiqiang Yan, Xiuzhuang Li, Yuhui Zhao, Rongbing Han, and Bo Qin*. Characterization of rhizosphere and endophytic fungal communities from roots of Stipa purpurea in alpine steppe around Qinghai Lake. Canadian Journal of Microbiology, 2016, 62, 643–656.
28. Le Pan, Xiuzhuang Li, Zhiqiang Yan, Hongru Guo and Bo Qin*. Phytotoxicity of umbelliferone and its analogs: Structureeactivity relationships and action mechanisms. Plant Physiology and Biochemistry, 2015, 97, 272–277.
29. Xia Ren, Xiaofeng He, Zhongfeng Zhang, Zhiqiang Yan, Hui Jin, Xiuzhuang Li, and Bo Qin*. Isolation, identification and autotoxicity effect of allelochemicals from rhizosphere Soils of Flue-Cured tobacco. Journal of Agricultural and Food Chemistry, 2015, 63, 8975–8980.
30. Hui Jin, Xiaoyan Yang, Dengxue Lu, Chunjie Li, Zhiqiang Yan, Xiuzhuang Li, Liming Zeng, Bo Qin*. Phylogenic diversity and tissue specificity of fungal endophytes associated with the pharmaceutical plant, Stellera chamaejasmeL. revealed by a cultivation- independent approach. Antonie van Leeuwenhoek, 2015, 108(4), 835–850.
31. Zhiqiang Yan, Dandan Wang, Lan Ding, Haiyan Cui, Hui Jin, Xiao-Yan Yang, Jian-She Yang, Bo Qin*. Mechanism of artemisinin phytotoxicity action: Induction of reactive oxygen species and cell death in lettuce seedlings. Plant Physiology and Biochemistry, 2015, 88, 53–59.
32. Zhiqiang Yan, Liming Zeng, Hui Jin and Bo Qin*. Potential ecological roles of flavonoids from Stellera chamaejasme. Plant Signaling & Behavior, 2015, 10(3), e1001225-1–3.
33. Zhiqiang Yan, Hui Jin, Dandan Wang, Xiaoyan Yang, Bo Qin*. The Effect of Ellagic Acid on the Root Gravitropic Response in Arabidopsis thaliana. Russian Journal of Plant Physiology, 2015, 62(5), 664–669.
34. Liming Zeng, Hui Jin, Dengxue Lu, Xiaoyan Yang, Le Pan, Haiyan Cui, Xiaofeng He, Hongdeng Qiu, Bo Qin*. Isolation and identification of chemical constituents from the bacterium Bacillus sp. and their nematicidal activities. Journal of Basic Microbiology, 2015, 55, 1–6.
35. Haiyan Cui, Xiaoyan Yang, Dengxue Lu, Hui Jin*, Zhiqiang Yan, Jixiang Chen, Xiuzhuang Li and Bo Qin*. Isolation and characterization of bacteria from the rhizosphere and bulk soil of Stellera chamaejasme L. Canadian Journal of Microbiology, 2015, 61, 1–11.
36. Hongru Guo, Haiyan Cui, Hui Jin, Zhiqiang Yan, Lan Ding and Bo Qin*. Potential allelochemicals in root zone soils of Stellera chamaejasme L. and variations at different geographical growing sites. Plant Growth Regulation, 2015, 77(3), 335–342.

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